Publications

For each project, technical contribution of the platforms must be acknowledged and clearly stated in all publications and communications based on the use of the data produced.

Acknowledgments must be done as follows :
"We are most grateful to the Genomics Core Facility GenoA, member of Biogenouest and France Genomique and to the Bioinformatics Core Facility BiRD, member of Biogenouest and Institut Français de Bioinformatique (IFB) (ANR-11-INBS-0013) for the use of their resources and their technical support"
 

Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome.
Estelle Renard, Richard D. Walton, David Benoist, Fabien Brette, Gilles Bru-Mercier,  Sébastien Chaigne, Sabine Charron, Marion Constantin, Matthieu Douard, Virginie Dubes, Bastien Guillot,  Thomas Hof, Julie Magat, Marine E. Martinez, Cindy Michel, Néstor Pallares-Lupon, Philippe Pasdois, Alice Récalde,  Fanny Vaillant, Frédéric Sacher, Louis Labrousse, Julien Rogier, Florence Kyndt, Manon Baudic, Jean-Jacques Schott, Julien Barc, Vincent Probst, Marine Sarlandie, Céline Marionneau, ,Jesse L. Ashton, Mélèze Hocini, Michel Haïssaguerre, Olivier Bernus
JACC : Clinical electrophysiology Vol.9, N°8,2023 :1248-1261. https://doi.org/10.1016/j.jacep.2023.03.009

KiT-GENIE, the French genetic biobank of kidney transplantation.
Rokhaya Ba, Axelle Durand, Vincent Mauduit, Christine Chauveau, Stéphanie LeBas-Bernardet, Sonia Salle, PierrickGuérif, Martin Morin, Clémence Petit, Venceslas Douillard, Olivia Rousseau, Gilles Blancho, Clarisse Kerleau, Nicolas Vince, Magali Giral, Pierre-Antoine Gourraud and Sophie Limou
European Journal of Human Genetics volume 31, pages 1291–1299 (2023). https://doi.org/10.1038/s41431-023-01294-z

Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.
HaoYu Chen, Christian Dina, Aeron M. Small, Christian M. Shaffer, Rebecca T. Levinson, Anna Helgadóttir, Romain Capoulade, Hans Markus Munter, Andreas Martinsson, Benjamin J. Cairns, Linea C. Trudsø, Mary Hoekstra, Hannah A. Burr, Thomas W. Marsh, Scott M. Damrauer, Line Dufresne, Solena Le Scouarnec, David Messika-Zeitoun, Dilrini K. Ranatunga, Rachel A. Whitmer, Amélie Bonnefond, Garðar Sveinbjornsson, Ragnar Daníelsen, David O. Arnar, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daníel F. Gudbjartsson, Hilma Hólm, Jonas Ghouse, Morten Salling Olesen, Alex H. Christensen, Susan Mikkelsen, Rikke Louise Jacobsen, Joseph Dowsett, Ole Birger Vesterager Pedersen, Christian Erikstrup, Sisse R. Ostrowski, Regeneron Genetics Center, Christopher J. O’Donnell, Matthew J.Budoff, Vilmundur Gudnason, Wendy S. Post, Jerome I. Rotter, Mark Lathrop, Henning Bundgaard, Bengt Johansson, Johan Ljungberg, Ulf Näslund, Thierry Le Tourneau, J. Gustav Smith, Quinn S. Wells, Stefan Söderberg, Kári Stefánsson, Jean-Jacques Schott, Daniel J. Rader, Robert Clarke, JamesC.Engert, and George Thanassoulis on behalf of the Therapeutic targets for AoRtic stenosis using GEneTics (TARGET) Consortium
European Heart Journal (2023) 44, 1927–1939. https://doi.org/10.1093/eurheartj/ehad142

Osteoarthritic chondrocytes undergo a glycolysis‑related metabolic switch upon exposure to IL‑1b or TNF.
Anais Defois, Nina Bon, Alexandre Charpentier, Melina Georget, Nicolas Gaigeard, Frederic Blanchard, Antoine Hamel, Denis Waast, Jean Armengaud, Ophelie Renoult, Claire Pecqueur, Yves Maugars, Marie‑Astrid Boutet, Jerome Guicheux and Claire Vinatier
Cell Communication and Signaling (2023) 21:137. https://doi.org/10.1186/s12964-023-01150-z

Maternal prebiotic supplementation impacts colitis Development in offspring mice.
Amélie Lê, Amandine Selle, Philippe Aubert, Tony Durand, Carole Brosseau, Philippe Bordron, Erwan Delage, Samuel Chaffron, Camille Petitfils, Nicolas Cenac, Michel Neunlist, Marie Bodinier and Malvyne Rolli-Derkinderen
Journal Frontiers in Nutrition fnut.2022.988529. https://doi.org/10.3389/fnut.2022.988529

A cluster of broadly neutralizing IgG against BK polyomavirus in a repertoire dominated by IgM.
Ngoc-Khanh Nguyen, Marie-Claire Devilder, Laetitia Gautreau-Rolland, Cynthia Fourgeux, Debajyoti Sinha, Jeremie Poschmann, Maryvonne Hourmant, Céline Bressollette-Bodin, Xavier Saulquin, Dorian McIlroy
Life Science Alliance, vol 6 | no 4 | e202201567. http://doi.org/10.26508/lsa.202201567

Transcriptomic Analysis Reveals the Inability of Recombinant AAV8 to Activate Human Monocyte-Derived Dendritic Cells.
Samer Masri, Laure Carré, Nicolas Jaulin, Céline Vandamme, Célia Couzinié, Aurélien Guy-Duché, Jean-Baptiste Dupont, Allwyn Pereira, Eric Charpentier, Laurent David, Gwladys Gernoux, Mickaël Guilbaud and Oumeya Adjali
Int. J. Mol. Sci. 2023, 24, 10447. https://doi.org/10.3390/ijms241310447

Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia.
Emmanuel Montassier, Georgios D. Kitsios, Josiah E.Radder, Quentin Le Bastard, Brendan J. Kelly, Ariane Panzer, Susan V. Lynch, Carolyn S. Calfee, Robert P. Dickson, & Antoine Roquilly
Nature Medicine | Volume29 | November 2023 | 2793–2804. https://doi.org/10.1038/s41591-023-02617-9

Exploring the impact of dexamethasone on gene regulation in myeloma cells.
Victor Bessonneau-Gaborit, Jonathan Cruard, Catherine Guerin-Charbonnel, Jennifer Derrien, Jean-Baptiste Alberge, Elise Douillard, Magali Devic, Sophie Deshayes, Loïc Campion, FrankWestermann, Phillipe Moreau, Carl Herrmann, Jérémie Bourdon, Florence Magrangeas, Stéphane Minvielle
Life Science Alliance. vol 6 | no 9 | e202302195. http://doi.org/10.26508/lsa.202302195

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model.
Constance Delwarde, Claire Toquet, Pascal Aumond, Amir Hossein Kayvanjoo, Adrien Foucal, Benjamin Le Vely, Manon Baudic, Benjamin Lauzier, Stéphanie Blandin, Joëlle Véziers, Perrine Paul-Gilloteaux, Simon Lecointe, Estelle Baron, Ilaria Massaiu, Paolo Poggio, Séverine Rémy, Ignacio Anegon, Hervé Le Marec, Laurent Monassier, Jean-Jacques Schott, Elvira Mass, Julien Barc, Thierry Le Tourneau, JeanMerot, and Romain Capoulade
Cardiovascular Research (2023) 119, 759–771. https://doi.org/10.1093/cvr/cvac136

Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha.
Nicolas Sailliet, Hoa-Le Mai, Amandine Dupuy, Gaëlle Tilly, Cynthia Fourgeux, Martin Braud, Magali Giral, Jean-Michel Robert, Nicolas Degauque, Richard Danger, Jeremie Poschmann and Sophie Brouard
Front. Immunol. 14:1183714. https://doi.org/10.3389/fimmu.2023.1183714

ADAMTS12 is a stromal modulator in chronic liver disease.
Bassil Dekky, FidaAzar, Dominique Bonnier, Christine Monseur, Chiara Kalebić, Esther Arpigny, Alain Colige, Vincent Legagneux, Nathalie Thére
The FASEB Journal. 2023;37:e23237. https://doi.org/10.1096/fj.202200692RRRR

CARD11 gain of function upregulates BCL2A1 expression and promotes resistance to targeted therapies combination in B-cell lymphoma.
Salomé Decombis, Celine Bellanger, Yannick Le Bris, Candice Madiot, Jane Jardine, Juliana Carvalho Santos, Delphine Boulet, Christelle Dousset, Audrey Menard, Charlotte Kervoelen, Elise Douillard, Philippe Moreau, Stephane Minvielle, Agnes Moreau-Aubry, Benoit Tessoulin, Gael Roue, Nicolas Bidère, Steven Le Gouill, Catherine Pellat Deceunynck, and David Chiron
Blood 2 NOVEMBER 2023|VOLUME 142, NUMBER 18. https://doi.org/10.1182/blood.2023020211

A p53 score derived from TP53 CRIPSR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics.
Romane Durand, Geraldine Descamps, Christelle Dousset, Celine Bellanger, Sophie Maïga, Jean-Baptiste Alberge, Jennifer Derrien, Jonathan Cruard, Stephane Minvielle, Nicoletta Libera Lilli, Catherine Godon, Yannick Le Bris, Benoit Tessoulin, Martine Amiot, Patricia Gomez-Bougie, Cyrille Touzeau, Philippe Moreau, David Chiron, Agnes Moreau-Aubry, Catherine Pellat-Deceunynck
Blood 28 MARCH 2024 | VOLUME 143, NUMBER 13. https://doi.org/10.1182/blood.2023021581

Left Ventricular Abnormal Substrate In Brugada Syndrome.
Ghassen Cheniti, Michel Haissaguerre, Christian Dina, Tsukasa Kamakura, Josselin Duchateau, Frederic Sacher, Hugo-Pierre Racine, Elodie Surget, Floriane Simonet, Jean-Baptiste Gourraud, Soumaya Sridi, Hubert Cochet, Clementine Andre, Benjamin Bouyer, Remi Chauvel, Romain Tixier, Nicolas Derval, Thomas Pambrun, Remi Dubois, Pierre Jais, Koonlawee Nademanee, Richard Redon, Jean-Jacques Schott, Vincent Probst, Meleze Hocini, Julien Barc, and Olivier Bernus
JACC : Clinical electrophysiology Vol.9, N°10,2023 :2052-2053. https://doi.org/10.1016/j.jacep.2023.05.039

A Rat Model of Clinically Relevant Extracorporeal Circulation Develops Early Organ Dysfunctions.
Antoine Persello, Fouzia Souab, Virginie Aillerie, Edith Bigot, Manon Denis, Angélique Erraud, Thomas Pelé, Angélique Blangy-Letheule, Pierre Miniou, Philippe Guedat, Michel De Waard, Emmanuelle Abgueguen, Bertrand Rozec, and Benjamin Lauzier
Int. J. Mol. Sci. 2023, 24, 7338. https://doi.org/10.3390/ijms24087338

Deciphering Transcriptional Networks during Human Cardiac Development.
Robin Canac, Bastien Cimarosti, Aurore Girardeau, Virginie Forest, Pierre Olchesqui, Jeremie Poschmann, Richard Redon, Patricia Lemarchand, Nathalie Gaborit, Guillaume Lamirault.
Cells 2022 Dec 3;11(23):3915.  https://doi.org/10.3390/cells11233915

Human gut microbiota-reactive DP8α regulatory T cells, signature and related emerging functions.
Francine Jotereau, Joudy Alameddine, Raluca Teusan, Annabelle Pédron, Nicolas Jouand, Frédéric Altare, Emmanuelle Godefroy
Front Immunol 2022 Nov 21;13:1026994. https://doi.org/10.3389/fimmu.2022.1026994

Burden of rare variants in arrhythmogenic cardiomyopathy with right dominant form‐associated genes provides new insights for molecular diagnosis and clinical management.
Adeline Goudal, Matilde Karakachoff, Pierre Lindenbaum, Estelle Baron, Stéphanie Bonnaud, Florence Kyndt, Marine Arnaud, Damien Minois, Emmanuelle Bourcereau, Aurélie Thollet, Jean-François Deleuze, Emmanuelle Genin, François Wiart, Jean-Luc Pasquié, Vincent Galand, Frédéric Sacher, Christian Dina, Richard Redon, Stéphane Bezieau, Jean-Jacques Schott, Vincent Probst, Julien Barc.
Hum Mutat. 2022 Sep;43(9):1333-1342. https://doi.org/10.1002/humu.24436

Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis.
Sandrine Morel, Isabel C Hostettler, Georg R Spinner, …Richard Redon, …Philippe Bijlenga.
J Pers Med 2022 Aug 30;12(9):1410. https://doi.org/10.3390/jpm12091410

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-Arat model.
Constance Delwarde, Claire Toquet, Pascal Aumond, Amir Hossein Kayvanjoo, Adrien Foucal, Benjamin Le Vely, Manon Baudic, Benjamin Lauzier, Stéphanie Blandin, Joëlle Véziers, Perrine Paul-Gilloteaux, Simon Lecointe, Estelle Baron, Ilaria Massaiu, Paolo Poggio, Séverine Rémy, Ignacio Anegon, Hervé Le Marec, Laurent Monassier, Jean Jacques Schott, Elvira Mass, Julien Barc, Thierry Le Tourneau, Jean Merot, Romain Capoulade.
Cardiovasc Res 2022 Aug 24;cvac136. https://doi.org/10.1093/cvr/cvac136

Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.
Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, Floriane Simonet, … Eric Charpentier, Estelle Baron, Stéphanie Bonnaud, Simon Lecointe, Audrey Donnart, …Jean-Jacques Schott, Richard Redon, Connie R Bezzina.
Nature Genetics 2022 Apr 26. https://doi.org/10.1038/s41588-021-01007-6

Generation of human induced pluripotent stem cell lines from four unrelated healthy control donors carrying European genetic background.
Aurore Girardeau, Diane Atticus, Robin Canac, Bastien Cimarosti, Amandine Caillaud, Caroline Chariau, Floriane Simonet, Bertrand Cariou, Flavien Charpentier, Jean-Baptiste Gourraud, Vincent Probst, Nadjet Belbachir, Laurence Jesel, Patricia Lemarchand, Julien Barc, Richard Redon, Nathalie Gaborit, Guillaume Lamirault.
Stem Cell Res. 2021 Dec 28;59:102647. https://doi.org/10.1016/j.scr.2021.102647

Generation of CD34+CD43+ Hematopoietic Progenitors to Induce Thymocytes from Human Pluripotent Stem Cells.
Léa Flippe, Anne Gaignerie, Céline Sérazin, Olivier Baron, Xavier Saulquin, Ignacio Anegon, Laurent David, Carole Guillonneau.
Cells. 2022 Dec 14;11(24):4046. https://doi.org/10.3390/cells11244046

The IL32/BAFF axis supports prosurvival dialogs in the lymphoma ecosystem and is disrupted by NIK inhibition.
Salomé Decombis, Antonin Papin, Céline Bellanger, Clara Sortais, Christelle Dousset, Yannick Le Bris, Thiphanie Riveron, Stéphanie Blandin, Philippe Hulin, Benoit Tessoulin, Mathieu Rouel, Steven Le Gouill, Agnès Moreau-Aubry, Catherine Pellat-Deceunynck, David Chiron.
Haematologica. 2022 Dec 1;107(12):2905-2917. https://doi.org/10.3324/haematol.2021.279800

CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy.
Marion Drouin, Javier Saenz, Vanessa Gauttier, Berangere Evrard, Geraldine Teppaz, Sabrina Pengam, Caroline Mary, Ariane Desselle, Virginie Thepenier, Emmanuelle Wilhelm, Emmanuel Merieau, Camille Ligeron, Isabelle Girault, Maria-Dolores Lopez, Cynthia Fourgeux, Debajyoti Sinha, Irene Baccelli, Aurelie Moreau, Cedric Louvet, Regis Josien, Jeremie Poschmann, Nicolas Poirier, Elise Chiffoleau.
Sci Adv. 2022 Nov 16;8(46):eabo7621. https://doi.org/10.1126/sciadv.abo7621

Patients with severe multiple sclerosis exhibit functionally altered CD8+ regulatory T cells.
Nail Benallegue, Bryan Nicol, Juliette Lasselin, Severine Bézie, Lea Flippe, Hadrien Regue, Nadege Vimond, Severine Remy, Alexandra Garcia, Fabienne Le Frère, Ignacio Anegon, David Laplaud, Carole Guillonneau
Neurol Neuroimmunol Neuroinflamm. 2022 Oct 20;9(6):e200016. https://doi.org/10.1212/NXI.0000000000200016

Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile.
Antoine Rimbert, Ming W Yeung, Nawar Dalila, Chris H L Thio, Haojie Yu, Natalia Loaiza, Federico Oldoni, Adriaan van der Graaf, Siqi Wang, M Abdullah Said, Lisanne L Blauw, Aurore Girardeau, Lise Bray, Amandine Caillaud, Vincent W Bloks, Marie Marrec, Philippe Moulin, Patrick C N Rensen, Bart van de Sluis, Harold Snieder, Mathilde Di Filippo, Pim van der Harst, Anne Tybjaerg-Hansen, Philip Zimmerman, Bertrand Cariou, Jan Albert Kuivenhoven.
Arterioscler Thromb Vasc Biol. 2022 Oct;42(10):1262-1271. https://doi.org/10.1161/ATVBAHA.122.317514

Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties.
Thomas L Bonneaud, Chloé C Lefebvre, Lisa Nocquet, Agnes Basseville, Julie Roul, Hugo Weber, Mario Campone, Philippe P Juin, Frédérique Souazé.
Cell Death Dis. 2022 Sep 14;13(9):787. https://doi.org/10.1038/s41419-022-05214-9
 
Quantification of APOBEC3 Mutation Rates Affecting the VP1 Gene of BK Polyomavirus In Vivo.
Dorian McIlroy, Cécile Peltier, My-Linh Nguyen, Louise Manceau, Lenha Mobuchon, Nicolas Le Baut, Ngoc-Khanh Nguyen, Minh-Chau Tran, The-Cuong Nguyen, Céline Bressollette-Bodin.
Viruses. 2022 Sep 19;14(9):2077. https://doi.org/10.3390/v14092077

Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma.
Gwennan André-Grégoire, Clément Maghe, Tiphaine Douanne, Sara Rosińska, Fiorella Spinelli, An Thys, Kilian Trillet, Kathryn A Jacobs, Cyndie Ballu, Aurélien Dupont, Anne-Marie Lyne, Florence M G Cavalli, Ignacio Busnelli, Vincent Hyenne, Jacky G Goetz, Nicolas Bidère, Julie Gavard.
iScience. 2022 Sep 13;25(10):105118. https://doi.org/10.1016/j.isci.2022.105118

Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro.
Marina A Heuschkel, Anne Babler, Jonas Heyn, Emiel P C van der Vorst, Marja Steenman, Maren Gesper, Ben A Kappel, David Magne, Yann Gouëffic, Rafael Kramann, Willi Jahnen-Dechent, Nikolaus Marx, Thibaut Quillard, Claudia Goettsch.
Front Cardiovasc Med. 2022 Sep 20;9:959457. https://doi.org/10.3389/fcvm.2022.959457

Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury.
Tanguy Chaumette, Raphael Cinotti, Alice Mollé, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E G McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cédric Jacqueline, Mickael Vourc'h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Régis Josien, Jose A Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, Antoine Roquilly.
Am J Respir Crit Care Med . 2022 Aug 1;206(3):295-310. https://doi.org/10.1164/rccm.202110-2324OC

Molecular Signature of 18F-FDG PET Biomarkers in Newly Diagnosed Multiple Myeloma Patients: A Genome-Wide Transcriptome Analysis from the CASSIOPET Study.
Jean-Baptiste Alberge, Françoise Kraeber-Bodéré, Bastien Jamet, Cyrille Touzeau, Hélène Caillon, Soraya Wuilleme, Marie-Christine Béné, Tobias Kampfenkel, Pieter Sonneveld, Mark van Duin, Herve Avet-Loiseau, Jill Corre, Florence Magrangeas, Thomas Carlier, Caroline Bodet-Milin, Michel Chérel, Philippe Moreau, Stéphane Minvielle, Clément Bailly.
J Nucl Med. 2022 Jul;63(7):1008-1013. https://doi.org/10.2967/jnumed.121.262884

The DCMU Herbicide Shapes T-cell Functions By Modulating Micro-RNA Expression Profiles.
Pierre Autin, Sophie Deshayes, Juliette Lea, Nicolas Boisgerault, Emilie Dupré, Nathalie Labarrière, Rémy Leguevel, Jean-François Fonteneau, Christophe Blanquart, Delphine Fradin.
Front Immunol. 2022 Jul 28;13:925241. https://doi.org/10.3389/fimmu.2022.925241

Moment Estimators of Relatedness From Low-Depth Whole-Genome Sequencing Data.
Anthony F Herzig, M Ciullo; FranceGenRef Consortium; A-L Leutenegger, H Perdry.
BMC Bioinformatics. 2022 Jun 24;23(1):254. https://doi.org/10.1186/s12859-022-04795-8

Beneficial Effects of O-GlcNAc Stimulation in a Young Rat Model of Sepsis: Beyond Modulation of Gene Expression.
Thomas Dupas, Antoine Persello, Angélique Blangy-Letheule, Manon Denis, Angélique Erraud, Virginie Aillerie, Aurélia A Leroux, Matthieu Rivière, Jacques Lebreton, Arnaud Tessier, Bertrand Rozec, Benjamin Lauzier.
Int J Mol Sci. 2022 Jun 9;23(12):6430. https://doi.org/10.3390/ijms23126430

Human and insect cell-produced rAAVs show differences in genome heterogeneity.
Ngoc Tam Tran, Mrs. Emilie Lecomte, Sylvie Saleun, Suk Namkung, Cecile Robin, Kristina Weber, Dr. Eric Devine, Veronique Blouin, Oumeya ADJALI, Eduard Ayuso, Guangping Gao, Magalie Penaud-Budloo, and Phillip W.L. Tai.
Human Gene Therapy 2022. Apr;33(7-8):371-388. https://doi.org/10.1089/hum.2022.050

Generation of human induced pluripotent stem cell lines from three patients affected by Catecholaminergic Polymorphic ventricular tachycardia (CPVT) carrying heterozygous mutations in RYR2 gene.
Bastien Cimarosti, Robin Canac, Stephan De Waard, Aurore Girardeau, Anne Gaignerie, Aude Derevier, Virginie Forest, Michel Ronjat, Hervé Le Marec, Jean-Baptiste Gourraud, Patricia Lemarchand, Michel De Waard, Guillaume Lamirault, Nathalie Gaborit.
Stem Cell Research; Volume 60, April 2022, 102688. https://doi.org/10.1016/j.scr.2022.102688

Rare germline heterozygous missense variants in BRCA1-associated protein 1, BAP1, cause a syndromic neurodevelopmental disorder.
Sébastien Küry, Frédéric Ebstein, Alice Mollé, …Bertrand Isidor.
Am J Hum Genet. 2022 Feb 3;109(2):361-372. https://doi.org/10.1016/j.ajhg.2021.12.011

Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes.
Yoann Combot, Veijo T Salo, Gilliane Chadeuf, Maarit Hölttä, Katharina Ven, Ilari Pulli, Simon Ducheix, Claire Pecqueur, Ophélie Renoult, Behnam Lak, Shiqian Li, Leena Karhinen, Ilya Belevich, Cedric Le May, Jennifer Rieusset, Soazig Le Lay, Mikael Croyal, Karim Si Tayeb, Helena Vihinen, Eija Jokitalo, Kid Törnquist, Corinne Vigouroux, Bertrand Cariou, Jocelyne Magré, Abdelhalim Larhlimi, Elina Ikonen, Xavier Prieur.
Cell Rep. 2022 Jan 11;38(2):110213. https://doi.org/10.1016/j.celrep.2021.110213
 

3’ RNA sequencing for robust and low-cost gene expression profiling
E. Charpentier, M. Cornec, S. Dumont, D. Meistermann, P. Bordron, L. David, R. Redon, S. Bonnaud, A. Bihouée
https://doi.org/10.21203/rs.3.pex-1336/v1 

DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies
S. Rose, M. Cuvellier, F. Ezan, J. Carteret, A. Bruyère, V. Legagneux, F. Nesslany, G. Baffet and S. Langouët
Archives of Toxicology (2021) | https://doi.org/10.1007/s00204-021-03178-x

PCSK9 is not secreted from mature differentiated intestinal cells
Moreau F., A. Thédrez, D. Garçon, A. Ayer T. Sotin, W. Dijk, C. Blanchard, G. Chadeuf, L. Arnaud, M. Croyal, L. Van Landeghem, M. Touvron, X. Prieur, A. Roubtsova, N. Seidah, A. Prat, B. Cariou, C. Le May
Journal of Lipid Research, 2021 | https://doi.org/10.1016/j.jlr.2021.100096

Probiotics impact the antibiotic resistance gene reservoir along the human GI tract in a person-specific and antibiotic-dependent manner
Emmanuel Montassier, Rafael Valdés-Mas, Eric Batard, Niv Zmora4, Mally Dori-Bachash, Jotham Suez and Eran Elinav
Nature Microbiology 2021 | https://doi.org/10.1038/s41564-021-00920-0

The Caspase-1/IL-18 Axis of the Inflammasome in Tumor Cells:A Modulator of the Th1/Tc1 Response of Tumor-Infiltrating TLymphocytes in Colorectal Cancer
Mutala, L.B.; Deleine, C.; Karakachoff, M.; Dansette, D.; Ducoin, K.; Oger, R.; Rousseau, O.; Podevin, J.; Duchalais, E.; Fourquier,P.; El Alami Thomas, W.; Gourraud, PA. ; , Bennouna, J. ; Brochier, C. ; Gervois N. ; Bossard, C. and Jarry, A.
Cancers 2021,13,89 | https://doi.org/10.3390/cancers13020189

Generation of proliferating human adult hepatocytes using optimized 3D culture conditions
S. Rose, F. Ezan, M. Cuvellier, A. Bruyère, V. Legagneux, S. Langouët & G. Baffet
Sci Rep 11, 515 (2021) | https://doi.org/10.1038/s41598-020-80019-4

Cadherin 2-Related Arrhythmogenic Cardiomyopathy: Prevalence and Clinical Features.
Ghidoni A, Elliott PM, Syrris P, Calkins H, James CA, Judge DP, Murray B, Barc J, Probst V, Schott J-J, Song J-P, Hauer RNW, Hoorntje ET, van Tintelen JP, Schulze-Bahr E, Hamilton RM, Mittal K, Semsarian C, Behr ER, Ackerman MJ, Basso C, Parati G, Gentilini D, Kotta M-C, Mayosi BM, Schwartz PJ, Crotti L.
Circ Genom Precis Med 2021 | https://doi.org/10.1161/CIRCGEN.120.003097

Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Mark K. Bakker , Rick A. A. van der Spek, Wouter van Rheenen , Sandrine Morel , Romain Bourcier, Isabel C. Hostettler , Varinder S. Alg, Kristel R. van Eijk, Masaru Koido , Masato Akiyama, Chikashi Terao , Koichi Matsuda , Robin G. Walters , Kuang Lin, Liming Li, Iona Y. Millwood, Zhengming Chen , Guy A. Rouleau , Sirui Zhou, Kristiina Rannikmäe , Cathie L. M. Sudlow, Henry Houlden , Leonard H. van den Berg, Christian Dina , Olivier Naggara, Jean-Christophe Gentric, Eimad Shotar, François Eugène , Hubert Desal, Bendik S. Winsvold , Sigrid Børte , Marianne Bakke Johnsen, Ben M. Brumpton , Marie Søfteland Sandvei , Cristen J. Willer , Kristian Hveem, John-Anker Zwart , W. M. Monique Verschuren, Christoph M. Friedrich , Sven Hirsch , Sabine Schilling , Jérôme Dauvillier , Olivier Martin, HUNT All-In Stroke*, China Kadoorie Biobank Collaborative Group*, BioBank Japan Project Consortium*, The ICAN Study Group*, CADISP Group*, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators*, International Stroke Genetics Consortium (ISGC)*, Gregory T. Jones , Matthew J. Bown , Nerissa U. Ko , Helen Kim , Jonathan R. I. Coleman , Gerome Breen, Jonathan G. Zaroff, Catharina J. M. Klijn , Rainer Malik, Martin Dichgans , Muralidharan Sargurupremraj, Turgut Tatlisumak, Philippe Amouyel , Stéphanie Debette , Gabriel J. E. Rinkel, Bradford B. Worrall, Joanna Pera, Agnieszka Slowik, Emília I. Gaál-Paavola, Mika Niemelä, Juha E. Jääskeläinen, Mikael von Und Zu Fraunberg, Antti Lindgren , Joseph P. Broderick, David J. Werring , Daniel Woo, Richard Redon , Philippe Bijlenga , Yoichiro Kamatani, Jan H. Veldink and Ynte M. Ruigrok
Nature Genetics 2021 | https://doi.org/10.1038/s41588-020-00725-7 

Transcriptomic Response of Breast Cancer Cells MDA-MB-231 to Docosahexaenoic Acid: Downregulation of Lipid and Cholesterol Metabolism Genes and Upregulation of Genes of the Pro-Apoptotic ER-Stress Pathway. 
Chénais B, Cornec M, Dumont S, Marchand J, Blanckaert V. 
Int. J. Environ. Res. Public Health 2020, 17(10), 3746  | https://doi.org/10.3390/ijerph17103746

Gap-134, a Connexin43 activator, prevents age-related development of ventricular fibrosis in Scn5a+/- mice. 
Patin J, Castro C, Steenman M, Hivonnait A, Carcouët A, Tessier A, Lebreton J, Bihouée A, Donnart A, Le Marec H, Baró I, Charpentier F, Derangeon M.
Pharmacol Res 2020;104922  | https://doi.org/10.1016/j.phrs.2020.104922

Relevance and diagnostic performance ofgenes involved in arrhythmogeniccardiomyopathy
A. Goudal, M. Karakachoff, P. Lindenbaum, E. Baron, S. Bonnaud, F. Kyndt, E. Bourcereau, A. Thollet, R. Redon, S. Bézieau, J.J. Schott, V. Probst, J. Barc
Archives of Cardiovascular Disease Supplements (2020)12, 261—265 |  https://doi.org/10.1016/j.acvdsp.2020.03.147

3D culture of HepaRG cells in GelMa and its application to bioprinting of a multicellular hepatic model
M. Cuvelliera, F. Ezana, H. Oliveirab, S. Rosea, J.C. Fricain, S. Langouet, V. Legagneux, G. Baffet
Biomaterials V 269, February 2021, 120611 | https://doi.org/10.1016/j.biomaterials.2020.120611

Induction of Human Trophoblast Stem Cells fromSomatic Cells and Pluripotent Stem Cells
G. Castel, D. Meistermann, B. Bretin, J. Firmin, J. Blin, S. Loubersac, A. Bruneau, S. Chevolleau, S. Kilens, C. Chariau, A. Gaignerie, Q. Francheteau, H. Kagawa, E. Charpentier, L. Flippe, V. F. Campion, S. Haider, B. Dietrich, M. Kno ̈fler, T. Arima, J. Bourdon, N. Rivron, D. Masson, T. Fournier, H. Okae, T. Freour and L. David
Cell Reports33, 108419, November 24, 20 | https://doi.org/10.1016/j.celrep.2020.108419

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma
J.B. Alberge, F. Magrangeas, M. Wagner, S. Denié, C. Guérin-Charbonnel, L. Campion, M. Attal, H. Avet-Loiseau, T. Carell, P. Moreau, S. Minvielle and A. Sérandour
Clin Epigenet (2020) 12:163 | https://doi.org/10.1186/s13148-020-00953-y

The SSV‐Seq 2.0 PCR‐free method improves the sequencing of adeno‐associated viral vector genomes containing GC‐rich regions and homopolymers
E. Lecomte, S. Saleun, M. Bolteau, A. Guy‐Duché, O. Adjali, V. Blouin, M. Penaud‐Budloo, E. Ayuso
Biotechnology Journal 16 October 2020 | https://doi.org/10.1002/biot.202000016

Transcriptome analysis of fetal rat testis following intrauterineexposure to the azole fungicides triticonazole andflusilazole revealssubtle changes despite adverse endocrine effects
M. K. Draskau, A. Lardenois, B. Evrard, J. Boberg,F. Chalmel, T. Svingen
Chemosphere, V 264, Part 1, February 2021, 128468 | https://doi.org/10.1016/j.chemosphere.2020.128468

Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma
M. Rabé, S. Dumont, A. Álvarez-Arenas, H. Janati, J. Belmonte-Beitia, G. F. Calvo, C. Thibault-Carpentier, Q. Séry, C. Chauvin, N. Joalland, F. Briand, S. Blandin, E. Scotet, C. Pecqueur, J. Clairambault, L. Oliver, V. Perez-Garcia, A. Nadaradjane, P.F. Cartron, C. Gratas and F. M. Vallette
Cell Death & Disease V11:19 (2020) | https://doi.org/10.1038/s41419-019-2200-2

Distribution of Bacterial α1,3-Galactosyltransferase Genes in the Human Gut Microbiome
E. Montassier, G. A. Al-Ghalith, C. Mathé, Q. Le Bastard, V. Douillard, A. Garnier, R. Guimon, B. Raimondeau, Y. Touchefeu, E. Duchalais, N. Vince, S. Limou, P.A. Gourraud, D. A. Laplaud, A. B. Nicot, J.P. Soulillou and L. Berthelot
Front. Immunol. 10:3000 (2020) | https://doi.org/10.3389/fimmu.2019.03000

Characterization of Glyceollins as Novel Aryl Hydrocarbon Receptor Ligands and Their Role in Cell Migration
Thu Ha Pham, Sylvain Lecomte, Remy Le Guevel, Aurélie Lardenois, Bertrand Evrard, Frédéric Chalmel, François Ferriere, Patrick Balaguer, Theo Efstathiou and Farzad Pakdel
Int. J. Mol. Sci. 2020, 21, 1368 | https://doi.org/10.3390/ijms21041368

Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes
Carolane Seiller,SophieMaiga, Cyrille Touzeau, Céline Bellanger, Charlotte Kervoëlen, Géraldine Descamps, Laurent Maillet, Philippe Moreau, Catherine Pellat-Deceunynck, Patricia Gomez-Bougie and Martine Amiot
Cell Death and Disease (2020) 11:316 | https://doi.org/10.1038/s41419-020-2505-1

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis
Antoine Roquilly, Cedric Jacqueline, Marion Davieau, Alice Mollé, Abderrahmane Sadek, Cynthia Fourgeux, Paul Rooze, Alexis Broquet, Barbara Misme-Aucouturier, Tanguy Chaumette, Mickael Vourc’h, Raphael Cinotti, Nadege Marec, Vanessa Gauttier, Hamish E. G. McWilliam, Frederic Altare, Jeremie Poschmann, Jose A. Villadangos & Karim Asehnoune 
Nature Immunology volume 21, pages636–648(2020) | https://doi.org/10.1038/s41590-020-0673-x

Maternal Protein Restriction in Rats Alters the Expression of Genes Involved in Mitochondrial Metabolism and Epitranscriptomics in Fetal Hypothalamus
Morgane Frapin, Simon Guignard, Dimitri Meistermann, Isabelle Grit, Valentine S. Moullé, Vincent Paillé, Patricia Parnet and Valérie Amarger
Nutrients 2020, 12, 1464 | https://doi.org/10.3390/nu12051464